Ethanol → Ethyl 7-oxo-7-phenylheptanoate

HRID 860422

反応式

HRID 860422 の反応式
[C:1]([CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O-][CH2:17][CH3:18].[Na+].C([OH:22])C>>[O:8]=[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:9][CH2:14][CH2:13][CH2:12][CH2:11][C:10]([O:15][CH2:17][CH3:18])=[O:22]

参加物

4

反応物 3

HCID 702EthanolHCID 2756272-BenzoylcyclohexanoneHCID 2723922Sodium ethoxide

生成物 1

HCID 11107694Ethyl 7-oxo-7-phenylheptanoate

実験手順

A mixture of 2-benzoylcyclohexanone (1.00 g), sodium ethoxide (404 mg) in ethanol (5 mL) was stirred for 3.5 hours at room temperature. The reaction was quenched by adding 1N hydrochloric acid (1 mL). The solvent was evaporated off, and the residue was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated to give ethyl 7-oxo-7-phenylheptanoate as a brown oil (1.33 g).

後処理

  1. customThe reaction was quenched
  2. additionby adding 1N hydrochloric acid (1 mL)
  3. customThe solvent was evaporated off
  4. customthe residue was partitioned between ethyl acetate and water
  5. washThe organic layer was washed with brine
  6. dry with materialdried over magnesium sulfate
  7. customevaporated

出典と根拠

ORDレコード
ord-c27831a485234b90b51bf50b96a7b44c
出典データセット
uspto-grants-2006_12
特許番号
US07153854B2

関連ノート

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