Ethanol → HCID 69589287、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([NH2:14])=[S:13])=[CH:10][N:9]=1.[CH3:17][O:18][C:19](=[O:27])[CH:20]([CH3:26])[C:21](=O)[CH:22](Br)[CH3:23].[CH2:28](O)C>>[CH2:17]([O:18][C:19](=[O:27])[CH:20]([C:21]1[N:14]=[C:12]([C:11]2[CH:10]=[N:9][C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])=[CH:16][CH:15]=2)[S:13][C:22]=1[CH3:23])[CH3:26])[CH3:28]参加物
4
実験手順
A mixture of 6-(2-Fluoro-phenyl)-thionicotinamide (3.0 g, 12 mmol) and 4-bromo-3-oxo-2-methyl-pentanoic acid methyl ester (3.2 g, 14.4 mmol) in ethanol (100 mL) is heated to reflux for 24 h, and concentrated. The residue is purified by column chromatography on silica gel yielding 2.6 g of the product.
後処理
- temperatureis heated
- temperatureto reflux for 24 h
- concentrationconcentrated
- customThe residue is purified by column chromatography on silica gel yielding 2.6 g of the product