関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Venlafaxine | HCID 5656 | — |
| 反応物 | 1-Dodecanethiol | HCID 8195 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 生成物 | Desvenlafaxine | HCID 125017 | — |
反応手順
Dodecanethiol (69 g), venlafaxine (55 g), and an ethanolic solution of sodium ethanolate (21%, 82 g) are charged to a pressure vessel. The temperature is raised to 150° C. and the reaction mixture is stirred for 2 days. Then the temperature is lowered and the solution is filtered. The pH of the filtrate is adjusted to 9.5 with aqueous hydrogen chloride. The crystals are collected by suction filtration. The cake is washed with ethanol and dried in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07154001B2 |
|---|
| 出典データセット | uspto-grants-2006_12 |
|---|
| ORD ID | ord-1f210c72ef1d4d6dbed5314b68ac8d0c |
|---|
| 出典メモ | uspto-grants-2006_12 |
|---|
