Isopropyl isocyanate → HCID 901017、化合物

HRID 861009ノート

反応式

HRID 861009 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.C1CCN2C(=NCCC2)CC1.[CH:20]([N:23]=[C:24]=[O:25])([CH3:22])[CH3:21]>C(Cl)Cl>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:24]([NH:23][CH:20]([CH3:22])[CH3:21])=[O:25])=[N:3][CH:4]=1

参加物

5

反応物 3

HCID 61277Isopropyl isocyanateHCID 706222-Amino-5-bromopyridineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

生成物 1

HCID 901017HCID 901017、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-amino-5-bromo-pyridine (1.05 eq.) in TBF (0.2M) was added DBU (1.0 eq.) followed by iso-propyl-isocyanate (1.0 eq.). The mixture was stirred for 12 h, diluted with CH2Cl2, washed with brine, dried over MgSO4, filtered and concentrated. Crystallization from acetone afforded the title compound as a white solid.

後処理

  1. washwashed with brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customCrystallization from acetone

出典と根拠

ORDレコード
ord-3f06e1b7e3ca49f1a12089c09a323654
出典データセット
uspto-grants-2006_12
特許番号
US07153968B2

反応ノート

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