Dimethylformamide dimethyl acetal → (E)-2-(2-chloro-4-pyrimidinyl)-3-(dimethylamino)-1-(4-fluorophenyl)-2-propen-1-one
反応式
[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1.CO[CH:20](OC)[N:21]([CH3:23])[CH3:22]>>[Cl:1][C:2]1[N:7]=[C:6](/[C:8](=[CH:20]\[N:21]([CH3:23])[CH3:22])/[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1参加物
3
実験手順
A mixture of the compound prepared in step 2 (4.7 g, 0.017 mol) in 100 mL of dimethylformamide dimethyl acetal was stirred at room temperature overnight. Excess dimethylformamide dimethyl acetal was removed under vacuum to give 4.5 g of crude product as a thick brown oil, which was used without further purification.
後処理
- customExcess dimethylformamide dimethyl acetal was removed under vacuum
出典と根拠
- ORDレコード
- ord-252e62eeb0464e8cbf76c5d8cb0035cb
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07153959B2
反応ノート
読み込み中…