Potassium Cyanide → 3-Amino-1-benzylpyrrolidine-3-carbonitrile
反応式
[CH2:1]([N:8]1[CH2:12][CH2:11][C:10](=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[NH4+:15].[C-:16]#[N:17].[K+]>>[NH2:15][C:10]1([C:16]#[N:17])[CH2:11][CH2:12][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:9]1参加物
4
実験手順
According to a particular variant of embodiment of this synthesis process, 1-benzyl-3-pyrrolidinone is treated with an ammoniacal solution of ammonium chloride and of potassium cyanide to obtain (±)-3-amino-1-benzyl-3-cyanopyrrolidine. This compound is then converted by acid or basic hydrolysis to (±)-3-amino-1-benzyl-3-pyrrolidinecarboxylic acid, and lastly a reduction with hydrogen, preferably a catalytic hydrogenolysis, is carried out to obtain (±)-3-amino-3-pyrrolidinecarboxylic acid or (±)-cucurbitine.
出典と根拠
- ORDレコード
- ord-e3c53c2e00aa496cb090918eb50af0b1
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05714164
反応ノート
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