Methyl tetrahydro-2,5-dimethoxyfuroate → 1-Cyclohexyl-6-trifluoromethyl-7-(2-methoxycarbonyl-1-pyrrolyl)-2,3(1H,4H)-quinoxalinedione

HRID 861461ノート

反応式

HRID 861461 の反応式
CO[C:3]([C:5]1(OC)[CH2:9][CH2:8][CH:7]([O:10][CH3:11])[O:6]1)=O.[CH:14]1([N:20]2[C:29]3[C:24](=[CH:25][C:26]([C:31]([F:34])([F:33])[F:32])=[C:27]([NH2:30])[CH:28]=3)[NH:23][C:22](=[O:35])[C:21]2=[O:36])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>COC1CCC(OC)O1.C(O)(=O)C>[CH:14]1([N:20]2[C:29]3[C:24](=[CH:25][C:26]([C:31]([F:32])([F:33])[F:34])=[C:27]([N:30]4[CH:3]=[CH:5][CH:9]=[C:8]4[C:7]([O:10][CH3:11])=[O:6])[CH:28]=3)[NH:23][C:22](=[O:35])[C:21]2=[O:36])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1

参加物

5

反応物 2

HCID 13152840Methyl tetrahydro-2,5-dimethoxyfuroateHCID 220971171-cyclohexyl-6-trifluoromethyl-7-amino-2,3(1H,4H)-quinoxalinedione

生成物 1

HCID 220972281-Cyclohexyl-6-trifluoromethyl-7-(2-methoxycarbonyl-1-pyrrolyl)-2,3(1H,4H)-quinoxalinedione

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 790982,5-Dimethoxytetrahydrofuran溶媒

実験手順

In place of 2,5-dimethoxytetrahydrofuran, 1.2 g (6.1 mmol) of 2-methoxycarbonyl-2,5-dimethoxytetrahydrofuran were dissolved with 2 g (6.1 mmol) of 1-cyclohexyl-6-trifluoromethyl-7-amino-2,3(1H,4H)-quinoxalinedione in 100 ml of acetic acid and refluxed for 30 minutes. The mixture was then worked up as in Example 3f.

後処理

  1. temperaturerefluxed for 30 minutes

出典と根拠

ORDレコード
ord-e2f80f1f39954b6d86bdaf19bba454ac
出典データセット
uspto-grants-1998_02
特許番号
US05714489

反応ノート

読み込み中…