Methyl tetrahydro-2,5-dimethoxyfuroate → 1-Cyclohexyl-7-(2-methoxycarbonyl-1-pyrrolyl)-6-nitro-2,3(1H,4H)-quinoxalinedione

HRID 861506ノート

反応式

HRID 861506 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:19])[C:8](=[O:18])[N:9]2[CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:4][C:3]=1[N+:20]([O-:22])=[O:21].[CH3:23][O:24][C:25]([C:27]1(OC)[CH2:31][CH2:30][CH:29](OC)O1)=[O:26]>C(O)(=O)C>[CH:12]1([N:9]2[C:10]3[C:5](=[CH:4][C:3]([N+:20]([O-:22])=[O:21])=[C:2]([N:1]4[CH:29]=[CH:30][CH:31]=[C:27]4[C:25]([O:24][CH3:23])=[O:26])[CH:11]=3)[NH:6][C:7](=[O:19])[C:8]2=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1

参加物

4

反応物 2

HCID 13152840Methyl tetrahydro-2,5-dimethoxyfuroateHCID 220970767-Amino-1-cyclohexyl-6-nitro-2,3(1H,4H)-quinoxalinedione2 回

生成物 1

HCID 220970791-Cyclohexyl-7-(2-methoxycarbonyl-1-pyrrolyl)-6-nitro-2,3(1H,4H)-quinoxalinedione収率 78.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

4.5 g (14.8 mmol) of 7-amino-1-cyclohexyl-6-nitro-2,3(1H,4H)-quinoxalinedione (product 37b) and 3.5 g (14.8 mmol) of 2-methoxycarbonyl-2,5-dimethoxytetrahydrofuran in 75 ml of acetic acid were refluxed for 2 h. The mixture was poured into ice-water, and the precipitate was filtered off with suction to yield 4.8 g (78%) of the product. Melting point 293° C. (decomposition).

後処理

  1. filtrationthe precipitate was filtered off with suction

出典と根拠

ORDレコード
ord-00ed290441a84cd5ad9e73cc0d184b7e
出典データセット
uspto-grants-1998_02
特許番号
US05714489

反応ノート

読み込み中…