Beta-Alanine → 3-{[2-Nitro-4-(trifluoromethyl)phenyl]amino}propanoic acid

HRID 861532ノート

反応式

HRID 861532 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[NH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19].C(=O)([O-])[O-].[K+].[K+].Cl>CN(C)C=O.O>[N+:12]([C:3]1[CH:4]=[C:5]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:7][C:2]=1[NH:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])([O-:14])=[O:13]

参加物

7

反応物 4

HCID 239Beta-AlanineHCID 313Hydrochloric AcidHCID 84624-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotolueneHCID 11430Potassium Carbonate

生成物 1

HCID 27643443-{[2-Nitro-4-(trifluoromethyl)phenyl]amino}propanoic acid収率 99%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

60 g (0.27 mol) of 2-chloro-1-nitro-5-trifluoromethylbenzene, 50 g (0.56 mol) of β-alanine and 41 g (0.3 mol) of potassium carbonate were refluxed in a mixture of 300 ml of dimethylformamide and 50 ml of water for 6 h. The mixture was then poured into ice-water, the aqueous phase was acidified with hydrochloric acid, and the precipitate was filtered off with suction to yield 73 g (99%) of the product.

後処理

  1. filtrationthe precipitate was filtered off with suction

出典と根拠

ORDレコード
ord-a89e95c159c44713b80e3f6faa196e3b
出典データセット
uspto-grants-1998_02
特許番号
US05714489

反応ノート

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