1-Octanethiol → 3,4,4-trifluoro-3-butenethioic acid, S-octyl ester

反応式

[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](Cl)=[O:5].[CH2:10]([SH:18])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]>>[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](=[O:5])[S:18][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

参加物

反応物 2

HCID 81441-Octanethiol

HCID 109207893,4,4-Trifluoro-3-butenoyl chloride

生成物 1

HCID 152391923,4,4-trifluoro-3-butenethioic acid, S-octyl ester収率 91.3%

反応条件

温度: 70 °C

実験手順

A mixture of 3,4,4-trifluoro-3-butenoyl chloride (1.7 g, 0.0107 mole) and 1-octanethiol (0.72 g, 0.0049 mole) is heated at 70° C. for 12 h. The crude product is purified by passing through a short column of silica gel to give 1.2 g of the desired product as a pale yellow oil, a 91% yield.

後処理

customThe crude product is purified

出典と根拠

ORDレコード: ord-aa454a550a084048bf8012a0c9405aaf
出典データセット: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05714517

反応ノート

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