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Methyl 3-phenyl-DL-alaninate hydrochloride → N-[(2-thiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 3-phenyl-DL-alaninate hydrochloride | HCID 3084017 | — |
| 反応物 | N-(thiazol-2-yl)-1H-imidazole-1-carbothioamide | HCID 10750950 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-[(2-thiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester | HCID 19704073 | 51% |
反応手順
A solution of 1-[(2-thiazolyl) thiocarbamoyl] imidazole (4.21 g, 20.0 mmol) and DL-phenylalanine methyl ester hydrochloride (4.31 g, 20.0 mmol) in N,N-dimethylformamide (150 mL) was heated at 90° C. for 3 h. The reaction was cooled to room temperature, solvent removed under reduced pressure, recrystallized from ether-hexanes to provide 3.26 g (51%) of the titled product:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05714503 |
| 出典データセット | uspto-grants-1998_02 |
| ORD ID | ord-62ce2b04828544049f96dfe862f60b8e |
| 出典メモ | uspto-grants-1998_02 |