Hydroxylamine → 3-Butyn-2-amine, 4-[3-(4-fluorophenoxy)phenyl]-N-hydroxy-

HRID 861686ノート

反応式

HRID 861686 の反応式
Br[CH:2]([C:4]#[C:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:7]=1)[CH3:3].[NH2:20][OH:21]>CN1CCCC1=O.O>[F:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][C:8]2[CH:7]=[C:6]([C:5]#[C:4][CH:2]([NH:20][OH:21])[CH3:3])[CH:11]=[CH:10][CH:9]=2)=[CH:14][CH:15]=1

参加物

5

反応物 2

HCID 787HydroxylamineHCID 108601322-Bromo-4-[3-(4-fluorophenoxy)phenyl]-3-butyne

生成物 1

HCID 107545733-Butyn-2-amine, 4-[3-(4-fluorophenoxy)phenyl]-N-hydroxy-

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

The 2-bromo-4-[3-(4-fluorophenoxy)phenyl]-3-butyne prepared in step 2 was taken up in N-methyl-2-pyrollidinone (27 kg) and 50% aqueous hydroxylamine (21 kg) was added. The reaction mixture was agitated for 2.5 hours at ambient temperature and then was diluted with distilled water (18 kg). The layers were separated and the organic phase was concentrated in vacuo to give N-[4-(3-(4-fluorophenoxy)phenyl)-3-butyn-2-yl]hydroxylamine.

後処理

  1. customThe layers were separated
  2. concentrationthe organic phase was concentrated in vacuo

出典と根拠

ORDレコード
ord-97e99734196f448398e6b0f34db326ac
出典データセット
uspto-grants-1998_02
特許番号
US05714633

反応ノート

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