関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acrylate | HCID 8821 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Acetylcyclohexanone | HCID 13400 | — |
| 触媒 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Acetyl-2-[2-(ethoxycarbonyl)ethyl]cyclohexanone | HCID 19067484 | 97% |
反応手順
To a solution of 2-acetylcyclohexanone (25 g, 0.18 mol), potassium carbonate (29.5 g, 0.21 mol) and benzyltriethylammonium chloride (0.8 g, 0.0035 mol) in toluene (70 ml) was added ethyl acrylate (29 ml, 27 g, 0.27 mol) at room temperature. The mixture was heated at 40° C. for 20 hours, filtered and partitioned between distilled water (200 ml) and toluene (200 ml). The organic layer was dried over magnesium sulphate, filtered and concentrated under reduced pressure to give the title compound as a brown oil, (41.7 g, 97%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05714628 |
|---|
| 出典データセット | uspto-grants-1998_02 |
|---|
| ORD ID | ord-84e3928876e44891a380435e78496325 |
|---|
| 出典メモ | uspto-grants-1998_02 |
|---|
