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Hydrochloric Acid → 2-Acetamido-6-methylbenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 6-Methylanthranilic acid | HCID 151210 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Acetamido-6-methylbenzoic acid | HCID 2801400 | — |
反応手順
90.6 g (0.6 mol) of 6-methylanthranilic acid are added to a solution of 24.8 g (0.62 mol) of NaOH in 500 ml of water and 63.4 g (0.62 mol) of acetic anhydride are then added dropwise. After stirring for one hour, the mixture is acidified to pH 3 with conc. HCl with cooling, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C. Yield: 107 g (0.55 mol)=92% of theory, m.p.: 189°-190° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05716905 |
| 出典データセット | uspto-grants-1998_02 |
| ORD ID | ord-2ddc99d5ca554895938e35503c3129e7 |
| 出典メモ | uspto-grants-1998_02 |