Ethylenediamine → 7-[N'-(2-aminoethyl)thioureido]-8-methylquinoline
反応式
[CH3:1][C:2]1[C:3]([N:12]=[C:13]=[S:14])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[CH2:15]([NH2:18])[CH2:16][NH2:17]>C(Cl)Cl.ClCl>[CH3:1][C:2]1[C:3]([NH:12][C:13]([NH:17][CH2:16][CH2:15][NH2:18])=[S:14])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2参加物
5
実験手順
A solution of 8-methyl-7-quinolinylisothiocyanate (1.36 g) in CH2Cl2 (50 mL) is added dropwise to ethylene diamine (2.26 mL) in solution in CH2 Cl2 (50 mL). The mixture is stirred for 30 minutes at room temperature then rotary evaporated. The residue is suspended in CH2 Cl2 (50 mL) and ether (50 mL) and filtered. The precipitate is dried in vacuo to afford N-(8-methyl-7-quinolinyl)-N'-2-aminoethylthiourea as a white powder.
後処理
- filtrationether (50 mL) and filtered
- customThe precipitate is dried in vacuo
出典と根拠
- ORDレコード
- ord-b36896087a374d96b3c7f31b43d3167f
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05716966
反応ノート
読み込み中…