Phenylhydrazine → 6-Phenyl-8-(3-nitrophenyl) pyrido[2,3-d]pyridazin-5-one

HRID 861952ノート

反応式

HRID 861952 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:19]=[CH:20][CH:21]=1)[C:7]([C:9]1[C:14]([C:15]([O:17]C)=O)=[CH:13][CH:12]=[CH:11][N:10]=1)=O)([O-:3])=[O:2].[C:22]1([NH:28][NH2:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(O)C>[C:22]1([N:28]2[C:15](=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[N:10][C:9]=3[C:7]([C:6]3[CH:19]=[CH:20][CH:21]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=3)=[N:29]2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

4

反応物 2

HCID 7516PhenylhydrazineHCID 197007162-(3-Nitrobenzoyl)-3-methoxycarbonylpyridine

生成物 1

HCID 538506476-Phenyl-8-(3-nitrophenyl) pyrido[2,3-d]pyridazin-5-one収率 21%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2-(3-nitrobenzoyl)-3-methoxycarbonylpyridine (0.26 g, 0.97 mmoles) dissolved in ethanol (50 ml), was added phenylhydrazine (0.25 ml, 2.4 mmoles). The mixture was refluxed for 168 hours. The solvent was removed and the solid was precipitated from ethanol and dried, yielding 0.07 g of 6-phenyl-8-(3-nitrophenyl) pyrido[2,3-d]pyridazin-5-one (21%), mp 167° C.

後処理

  1. temperatureThe mixture was refluxed for 168 hours
  2. customThe solvent was removed
  3. customthe solid was precipitated from ethanol
  4. customdried

出典と根拠

ORDレコード
ord-8f0f0911f84c4fb081874095f8476667
出典データセット
uspto-grants-1998_02
特許番号
US05716954

反応ノート

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