Chlorine → Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylate, monohydrochloride

HRID 861998ノート

反応式

HRID 861998 の反応式
[CH2:1]([O:3][P:4]([CH:9]([OH:24])[C:10]1[N:15]2[CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].P(CC1C2N(C=C(C(O)=O)N=2)C=CC=1)(O)(O)=O.O1CCOCC1.[Cl:48]Cl>>[ClH:48].[CH2:1]([O:3][P:4]([CH:9]([OH:24])[C:10]1[N:15]2[CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]

参加物

5

反応物 4

HCID 24526ChlorineHCID 312751,4-DioxaneHCID 15233873Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylateHCID 19701381HCID 19701381、化合物

生成物 1

HCID 131720464Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylate, monohydrochloride収率 99%

実験手順

The product from Example 55 (1.2 g, 3.37 mmol) was dissolved in CH2 Cl2 (15 mL) and treated with 6N HCl in dioxane (0.56 mL, 3.37 mmol). The resulting salt was precipitated with Et2O, filtered, washed with Et2O, and dried in vacuo to give 1.3 g (99%) of the title product.

後処理

  1. customThe resulting salt was precipitated with Et2O
  2. filtrationfiltered
  3. washwashed with Et2O
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-f854f89bc13243bfb3e84961edbbc3f3
出典データセット
uspto-grants-1998_02
特許番号
US05716964

反応ノート

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