Potassium Cyanide → Ethyl 5-(cyanomethyl)imidazo[1,2-a]pyridine-2-carboxylate

HRID 862001ノート

反応式

HRID 862001 の反応式
Cl[CH2:2][C:3]1[N:8]2[CH:9]=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1.[C-:17]#[N:18].[K+]>CN(C=O)C>[C:17]([CH2:2][C:3]1[N:8]2[CH:9]=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1)#[N:18]

参加物

4

反応物 2

HCID 9032Potassium CyanideHCID 19701283Ethyl 5-(chloromethyl)imidazo[1,2-a]pyridine-2-carboxylate

生成物 1

HCID 19701198Ethyl 5-(cyanomethyl)imidazo[1,2-a]pyridine-2-carboxylate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
0 °C

実験手順

Title material is made by dissolving the title product of Example 5 in DMF and after cooling to 0° C., reacting with KI and KCN. The reaction is stirred for 6 h at 0° C. After warming to room temperature, title compound is obtained by diluting with CHCl3, washing with water, and removing all solvent in vacuo.

後処理

  1. temperatureAfter warming to room temperature

出典と根拠

ORDレコード
ord-a9f32087fa6042738af023682b205495
出典データセット
uspto-grants-1998_02
特許番号
US05716964

反応ノート

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