Tributyltin azide → Ethyl 5-(1H-tetrazol-5-ylmethyl)imidazo[1,2-a]pyridine-2-carboxylate

HRID 862002ノート

反応式

HRID 862002 の反応式
[C:1]([CH2:3][C:4]1[N:9]2[CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:12]=[C:8]2[CH:7]=[CH:6][CH:5]=1)#[N:2].[N:18]([Sn](CCCC)(CCCC)CCCC)=[N+:19]=[N-:20]>P(CC1C2N(C=C(C(O)=O)N=2)C=CC=1)(O)(O)=O>[NH:18]1[C:1]([CH2:3][C:4]2[N:9]3[CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:12]=[C:8]3[CH:7]=[CH:6][CH:5]=2)=[N:2][N:20]=[N:19]1

参加物

4

反応物 2

HCID 4984872Tributyltin azideHCID 19701198Ethyl 5-(cyanomethyl)imidazo[1,2-a]pyridine-2-carboxylate

生成物 1

HCID 178469441Ethyl 5-(1H-tetrazol-5-ylmethyl)imidazo[1,2-a]pyridine-2-carboxylate

試薬・触媒・溶媒 1

HCID 19701381HCID 19701381、化合物溶媒2 回

実験手順

The title material is prepared by heating the title product of Example 99 with azido tributylstannane at 80° C. for 72 h. After cooling to room temperature, the reaction is treated with methanolic HCl for 30 min., diluted with 4N HCl, washed with diethyl ether and concentrated to yield title material.

後処理

  1. washwashed with diethyl ether
  2. concentrationconcentrated
  3. customto yield title material

出典と根拠

ORDレコード
ord-1add0950defb45b38b2876b3671ad414
出典データセット
uspto-grants-1998_02
特許番号
US05716964

反応ノート

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