2,5-Dimethoxybenzenemethanamine → (2R,3R,4R,6R)-2-Diphenylmethyl-3-(2,5-dimethoxybenzyl)amino-6-phenethyl-1-azabicyclo[2.2.2]octane

反応式

[C:1]1([CH:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C@@H:8]2[C:13](=O)[C@@H:12]3[CH2:15][CH2:16][N:9]2[C@H:10]([CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:11]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:31][O:32][C:33]1[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][C:34]=1[CH2:35][NH2:36]>>[C:25]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C@@H:8]2[C@H:13]([NH:36][CH2:35][C:34]3[CH:37]=[C:38]([O:41][CH3:42])[CH:39]=[CH:40][C:33]=3[O:32][CH3:31])[C@@H:12]3[CH2:15][CH2:16][N:9]2[C@H:10]([CH2:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:11]3)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

参加物

反応物 2

HCID 186522,5-Dimethoxybenzenemethanamine

HCID 54156123(2R*,4R*,6R*)-2-Diphenylmethyl-6-phenethylquinuclidin-3-one

生成物 1

HCID 53847961(2R*,3R*,4R*,6R*)-2-Diphenylmethyl-3-(2,5-dimethoxybenzyl)amino-6-phenethyl-1-azabicyclo[2.2.2]octane

実験手順

A compound of Example 4 were prepared from compound 7 and 2,5-dimethoxybenzylamine by the same procedure for Example 1.

出典と根拠

ORDレコード: ord-3e3128797aff4fd692102b361fc2a5e3
出典データセット: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05716965

反応ノート

読み込み中…