Trifluoroacetate → Pixantrone dimaleate

反応式

FC(F)(F)C([O-])=O.[NH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:17]2[C:18](=[O:27])[C:19]3[CH:20]=[CH:21][N:22]=[CH:23][C:24]=3[C:25](=[O:26])[C:16]=2[C:15]([NH:28][CH2:29][CH2:30][NH2:31])=[CH:14][CH:13]=1.[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36]>>[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36].[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36].[NH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:17]2[C:18](=[O:27])[C:19]3[CH:20]=[CH:21][N:22]=[CH:23][C:24]=3[C:25](=[O:26])[C:16]=2[C:15]([NH:28][CH2:29][CH2:30][NH2:31])=[CH:14][CH:13]=1

参加物

反応物 3

HCID 84468Trifluoroacetate2 回

HCID 134019Pixantrone

HCID 444266Maleic Acid2 回

生成物 1

HCID 9937618Pixantrone dimaleate

実験手順

exchanging the trifluoroacetate salt of 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione with maleic acid by treating the trifluoroacetate salt with an aqueous solution of maleic acid to form the crystallized 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate salt.

出典と根拠

ORDレコード: ord-09310a19981643cdbc36ee915c4fc748
出典データセット: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05717099

反応ノート

読み込み中…