2-(3,4-Dimethoxyphenyl)propan-2-amine → N-[1-(3,4-Dimethoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamide

HRID 862282

反応式

HRID 862282 の反応式
[C:1]([C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:22](=[O:30])SC2C=CC=CN=2)[CH:4]=1)#[N:2].[CH3:31][O:32][C:33]1[CH:34]=[C:35]([C:41]([NH2:44])([CH3:43])[CH3:42])[CH:36]=[CH:37][C:38]=1[O:39][CH3:40]>>[CH3:31][O:32][C:33]1[CH:34]=[C:35]([C:41]([NH:44][C:22]([C@H:12]2[CH2:11][CH2:10][C@H:9]3[C@H:8]4[C@H:17]([CH2:16][CH2:15][C@:13]23[CH3:14])[C@:18]2([CH3:21])[C:5]([CH:4]=[C:3]([C:1]#[N:2])[CH2:20][CH2:19]2)=[CH:6][CH2:7]4)=[O:30])([CH3:42])[CH3:43])[CH:36]=[CH:37][C:38]=1[O:39][CH3:40]

参加物

3

反応物 2

HCID 30322332-(3,4-Dimethoxyphenyl)propan-2-amineHCID 15380265S-2pyridyl 3-cyanoandrosta-3,5-diene-17beta-thiocarboxylate

生成物 1

HCID 57051570N-[1-(3,4-Dimethoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamide収率 60%

実験手順

Following a procedure similar to that described in Example 3(b), but using S-2-pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 1-(3,4-dimethoxyphenyl)-1-methylethylamine (prepared as described in Preparation 10e) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 60%.

出典と根拠

ORDレコード
ord-f814497772a4410b91fcbac7304e3e66
出典データセット
uspto-grants-1998_02
特許番号
US05717088

関連ノート

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