Pyrazole-4-carboxylic acid → Methyl 1H-pyrazole-4-carboxylate

HRID 862479ノート

反応式

HRID 862479 の反応式
[NH:1]1[CH:5]=[C:4]([C:6]([OH:8])=[O:7])[CH:3]=[N:2]1.[CH3:9][O-].[Na+]>CO.S(=O)(=O)(O)O>[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH3:9])=[O:7])[CH:3]=[N:2]1

参加物

5

反応物 2

HCID 3015937Pyrazole-4-carboxylic acidHCID 10942334Sodium Methoxide

生成物 1

HCID 9793760Methyl 1H-pyrazole-4-carboxylate

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 1118Sulfuric Acid溶媒

実験手順

4-Pyrazolecarboxylic acid (514 mg) was dissolved in methanol (10 ml) and sulfuric acid (0.25 ml), and the mixture was stirred at room temperature for 2 hours, followed by refluxing under heating for 4 hours. After cooling, a 28% solution (0.95 ml) of sodium methylate in methanol was added to the reaction mixture for neutralization and the solvent was distilled away. Chloroform was added to the residue, and the residue was washed with water and brine and dried over anhydrous magnesium sulfate. The solvent was distilled away to give 433 mg of the title compound.

後処理

  1. temperatureby refluxing
  2. temperatureunder heating for 4 hours
  3. temperatureAfter cooling
  4. distillationthe solvent was distilled away
  5. additionChloroform was added to the residue
  6. washthe residue was washed with water and brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. distillationThe solvent was distilled away

出典と根拠

ORDレコード
ord-03a04da955174a06bbf4cc1d968eb199
出典データセット
uspto-grants-1998_02
特許番号
US05719155

反応ノート

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