反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH:13][CH3:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH2:15]([O:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][C:19]=1[C:28]1[NH:33][C:32](=[O:34])[N:31]2[C:35]([CH3:41])=[N:36][C:37]([CH2:38][CH2:39][CH3:40])=[C:30]2[N:29]=1)[CH3:16]>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][N:13]([CH3:14])[S:24]([C:21]2[CH:22]=[CH:23][C:18]([O:17][CH2:15][CH3:16])=[C:19]([C:28]3[NH:33][C:32](=[O:34])[N:31]4[C:35]([CH3:41])=[N:36][C:37]([CH2:38][CH2:39][CH3:40])=[C:30]4[N:29]=3)[CH:20]=2)(=[O:25])=[O:26])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
143 mg (0.73 mmol) of N-(3,4-dimethoxyphenylethyl)-N-methylamine are added to a solution of 100 mg (0.24 mmol) of 4-ethoxy-3-(6-methyl-4-oxo-8-propyl-3,4-dihydro-imidazo[1,5-a][1,3,5]triazin-2-yl)-benzenesulfonyl chloride (example VI) in 5 ml of dichloromethane and the reaction mixture is stirred at room temperature for 2 hours. After chromatographic purification (dichloromethane/methanol=95:5), 138 mg (98%) of N-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-ethoxy-N-methyl-3-(6-methyl-4-oxo-8-propyl-3,4-dihydro-imidazo[1,5-a][1,3,5]triazin-2-yl)-benzene-sulfonamide are obtained.
後処理
- customAfter chromatographic purification (dichloromethane/methanol=95:5), 138 mg (98%) of N-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-ethoxy-N-methyl-3-(6-methyl-4-oxo-8-propyl-3,4-dihydro-imidazo[1,5-a][1,3,5]triazin-2-yl)-benzene-sulfonamide
- customare obtained
出典と根拠
- ORDレコード
- ord-936d5bb6add248b09e6db41a86e6f77c
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07091203B2
関連ノート
読み込み中…