Imidazole → HCID 22097613、化合物

HRID 862660ノート

反応式

HRID 862660 の反応式
Br[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:6].[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[N:15]1([CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:6])[CH:19]=[CH:18][N:17]=[CH:16]1

参加物

5

反応物 3

HCID 795ImidazoleHCID 11430Potassium CarbonateHCID 3832489Benzyl 4-bromobutanoate

生成物 1

HCID 22097613HCID 22097613、化合物収率 33%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of benzyl 4-bromobutyrate (23.7 g), imidazole (8.1 g), potassium carbonate (14.0 g) and acetone (400 ml) was stirred under reflux for 6 hours. After cooling the mixture to room temperature, the insoluble material was filtered off, and the filtrate was concentrated. The residual oil was subjected to column chromatography on silica gel. The fractions eluted with ethyl acetate/methanol (20/1, v/v) gave benzyl 4-(1-imidazolyl)butyrate (7.3 g, 33%) as an oil.

後処理

  1. temperatureunder reflux for 6 hours
  2. filtrationthe insoluble material was filtered off
  3. concentrationthe filtrate was concentrated
  4. washThe fractions eluted with ethyl acetate/methanol (20/1

出典と根拠

ORDレコード
ord-05a5c7de65b0473ba1240975da31d788
出典データセット
uspto-grants-1998_02
特許番号
US05719157

反応ノート

読み込み中…