反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([OH:19])[C:8]([C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])=[N:9]2)=[CH:4][C:3]=1[O:20][CH2:21][C:22]([F:25])([F:24])[F:23]>C(O)=O>[ClH:1].[OH:19][C:7]1[C:8]([C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])=[N:9][C:10]2[C:5]([CH:6]=1)=[CH:4][C:3]([O:20][CH2:21][C:22]([F:25])([F:23])[F:24])=[CH:2][CH:11]=2参加物
3
実験手順
0.5 g (1.3 mmol) of N-((7-chloro-3-hydroxy-6-(2,2,2-trifluoroethyloxy)quinolin-2-yl)carbonyl)glycine (title compound from Example 31) was dissolved in 26 ml of methanolic formic acid (4.4% strength), and a further 26 ml of methanolic formic acid were added at 20° C. After addition of 0.5 g of Pd/C (10%), the mixture was stirred at 20° C. for 1 hour, the catalyst was filtered off, the filtrate was concentrated and the residue was crystallized with diisopropyl ether. 250 mg of product were obtained, melting point >300° C. (sintering at 207° C.).
出典と根拠
- ORDレコード
- ord-43951013e5f7467e9eb94d20cac1e343
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05719164
関連ノート
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