Hydrochloric Acid → N-Glycyl-3(R)-methyl-beta-alanine benzyl ester hydrochloride
反応式
[CH2:1]([O:8][C:9](=[O:25])[CH2:10][C@@H:11]([CH3:24])[NH:12][C:13](=[O:23])[CH2:14][NH:15]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:26]>CCOC(C)=O>[ClH:26].[CH2:1]([O:8][C:9](=[O:25])[CH2:10][C@@H:11]([CH3:24])[NH:12][C:13](=[O:23])[CH2:14][NH2:15])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
N-t-Butoxycarbonylglycyl-3(R)-methyl-β-alanine benzyl ester 2-4 (3.32 g) in EtOAc (100 mL) cooled to -60° C. was treated with HCl gas until saturated. The mixture was stirred for 30 minutes then the solvent was removed and the residue triturated with ether to give 2-5 as a solid. ##STR59## N-{[6-Nitro-2,3-dihydro-1(1H)-isoindolone-2-yl]acetyl}-3(R) -methyl-β-alanine benzyl ester (2-6)