1-Bromoundecane → 3-(3-Undecyloxyphenyl)propanol

HRID 862820ノート

反応式

HRID 862820 の反応式
[CH2:1](Br)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[OH:13][C:14]1[CH:15]=[C:16]([CH2:20][CH2:21][CH2:22][OH:23])[CH:17]=[CH:18][CH:19]=1>C(O)C>[CH2:1]([O:13][C:14]1[CH:15]=[C:16]([CH2:20][CH2:21][CH2:22][OH:23])[CH:17]=[CH:18][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

参加物

4

反応物 2

HCID 127441-BromoundecaneHCID 103518713-Hydroxybenzenepropanol

生成物 1

HCID 218493913-(3-Undecyloxyphenyl)propanol収率 80.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
70 °C

実験手順

A 15N aqueous sodium hydroxide solution (2 ml) and a solution (10 ml) of 8.0 g of undecyl bromide in ethanol was added to a solution (30 ml) of 4.56 g of 3-(3-hydroxyphenyl)propanol in ethanol and the mixture was stirred at 70° C. for 12 hours. The solvent was distilled away and the residue was extracted with ethyl acetate. The extract was washed with saturated sodium hydrogencarbonate and brine, and dried over magnesium sulfate. The solvent was distilled away and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:20-1:3) to give 7.37 g of 3-(3-undecyloxyphenyl)propanol as a colorless, oily substance.

後処理

  1. distillationThe solvent was distilled away
  2. extractionthe residue was extracted with ethyl acetate
  3. washThe extract was washed with saturated sodium hydrogencarbonate and brine
  4. dry with materialdried over magnesium sulfate
  5. distillationThe solvent was distilled away
  6. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:20-1:3)

出典と根拠

ORDレコード
ord-41069501638c407caabf5cb0f31953ca
出典データセット
uspto-grants-1998_02
特許番号
US05719176

反応ノート

読み込み中…