Acetamidomalonic acid diethyl ester → Diethyl 2-acetamido-2-(12-tetrahydropyranyloxydodecyl)malonate

HRID 862832

反応式

HRID 862832 の反応式
[C:1]([NH:4][CH:5]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2].[O-]CC.[Na+].Br[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][O:33][CH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][O:35]1>C(O)C>[C:1]([NH:4][C:5]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][O:33][CH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][O:35]1)([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 14041Acetamidomalonic acid diethyl esterHCID 2723922Sodium ethoxideHCID 110785922H-Pyran, 2-[(12-bromododecyl)oxy]tetrahydro-

生成物 1

HCID 21849423Diethyl 2-acetamido-2-(12-tetrahydropyranyloxydodecyl)malonate収率 39.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Diethyl acetamidomalonate (6.996 g) and 3.189 g of sodium ethoxide were dissolved in 130 ml of dry ethanol and a solution of 10.698 g of 1-bromo-12-tetrahydropyranyloxydodecane in 200 ml of dry ethanol was added thereto. The mixture was refluxed under heating for 8 hours. The solvent was distilled away under reduced pressure and the residue was purified by silica gel column chromatography to give 5.837 g of diethyl 2-acetamido-2-(12-tetrahydropyranyloxydodecyl)malonate.

後処理

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating for 8 hours
  3. distillationThe solvent was distilled away under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-b9e03d9ea2a4433f88a7091e3e09ef8d
出典データセット
uspto-grants-1998_02
特許番号
US05719176

関連ノート

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