Acetyl chloride → L-Norvaline, methyl ester

HRID 863187ノート

反応式

HRID 863187 の反応式
[C:1](Cl)(=O)C.[NH2:5][C@H:6]([C:10]([OH:12])=[O:11])[CH2:7][CH2:8][CH3:9]>CO>[CH3:1][O:11][C:10](=[O:12])[C@H:6]([CH2:7][CH2:8][CH3:9])[NH2:5]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 65098L-Norvaline

生成物 1

HCID 7019097L-Norvaline, methyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 20 mL of methanol was slowly added 2.6 mL acetyl chloride. Then 2.0 g (17.1 mmole) of L-norvaline was added. The solution was heated to reflux and monitored by thin-layer chromatography (TLC) until complete. The methanol was stripped off by rotary evaporation and the resulting oil was pumped under high vacuum overnight to give the title compound. NMR(300 MHZ, CD3OD): δ 4.03 (t, Nva-α, 1H), 3.81 (s, COOCH3, 3H), 1.87 (m, CH2CH2CH3, 2H), 1.44 (m, CH2CH2CH3, 2H), 0.98 (t, CH2CH2CH3, 3H).

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux
  3. customThe methanol was stripped off by rotary evaporation
  4. customwas pumped under high vacuum overnight

出典と根拠

ORDレコード
ord-d038bcdebc68470bb7cdd8f58e0a9df3
出典データセット
uspto-grants-1998_02
特許番号
US05719296

反応ノート

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