関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Butylamine | HCID 8007 | — |
| 反応物 | Methyl 1,2,3,4-tetrahydro-3-quinolinecarboxylate | HCID 283526 | — |
| 生成物 | 3(R,S)-butylaminocarbonyl-1,2,3,4-tetrahydroquinoline | HCID 19697883 | — |
反応手順
A mixture of 500 mg of 3(R,S)-methoxycarbonyl-1,2,3,4-tetrahydroquinoline (Example 1r) and 1 ml of n-butylamine is stirred at 60° C. for 1 h. Purification of the crude product by means of FC over 50 g of silica gel (mobile phase Z) gives 3(R,S)-butylaminocarbonyl-1,2,3,4-tetrahydroquinoline: Rf (Z)=0.21.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05719141 |
|---|
| 出典データセット | uspto-grants-1998_02 |
|---|
| ORD ID | ord-a3f062c980fa403cad2cdac12411e63c |
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| 出典メモ | uspto-grants-1998_02 |
|---|
