Bromine → N-(5-acetylamino-6-bromo-indan-2-yl)acetamide
反応式
[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH2:10][CH:9]([NH:14][C:15](=[O:17])[CH3:16])[CH2:8]2)(=[O:3])[CH3:2].[Br:18]Br>C(O)(=O)C>[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[Br:18])[CH2:10][CH:9]([NH:14][C:15](=[O:17])[CH3:16])[CH2:8]2)(=[O:3])[CH3:2]参加物
4
実験手順
A solution of N-(5-acetylamino-indan-2-yl)-acetamide (9.8 g, 42 mmol) and bromine (8.5 g, 53 mmol) in acetic acid (200 mL) was stirred at room temperature for 3 h. After evaporation of the solvent, the syrupy residue was dissolved in ether and washed with water. The organic layer was washed with aqueous sodium bisulfite and dried over magnesium sulfate. The solvent was concentrated and the resulting solid collected by filtration (10 g, 77% yield).
後処理
- customAfter evaporation of the solvent
- dissolutionthe syrupy residue was dissolved in ether
- washwashed with water
- washThe organic layer was washed with aqueous sodium bisulfite
- dry with materialdried over magnesium sulfate
- concentrationThe solvent was concentrated
- filtrationthe resulting solid collected by filtration (10 g, 77% yield)
出典と根拠
- ORDレコード
- ord-021d9269f5a9443ba7e198ae3b6dd52c
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05721234
反応ノート
読み込み中…