Dimethyl Sulfate → N-(7-methoxynaphthalen-1-yl)acetamide

HRID 863505ノート

反応式

HRID 863505 の反応式
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[CH:13]=[C:12]([OH:15])[CH:11]=[CH:10]2)(=[O:3])[CH3:2].S(OC)(O[CH3:20])(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[CH:13]=[C:12]([O:15][CH3:20])[CH:11]=[CH:10]2)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 809461-Acetamido-7-naphthol

生成物 1

HCID 11447230N-(7-methoxynaphthalen-1-yl)acetamide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 8-Acetamido-2-naphthol (21 g, 0.104 mol), dimethyl sulfate (15.1 g, 0.12 mol) and potassium carbonate (41 g, 0.3 mol) in acetone (200 mL) was stirred at room temperature for 48 h. Solids were removed by filtration and washed with methanol, and the filtrate evaporated. The residue was washed in 1:1 hexane:toluene, collected by filtration and dried (24.7 g).

後処理

  1. customSolids were removed by filtration
  2. washwashed with methanol
  3. customthe filtrate evaporated
  4. washThe residue was washed in 1:1 hexane
  5. filtrationtoluene, collected by filtration
  6. customdried (24.7 g)

出典と根拠

ORDレコード
ord-6af2e0d4890a4fea8e82f0200997e77e
出典データセット
uspto-grants-1998_02
特許番号
US05721234

反応ノート

読み込み中…