化工社化工社 化学情報印刷レポート · 研究参考用
1,2-Dibromoethane → (2-Bromo-ethyl)-(3-fluorobenzyl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dibromoethane | HCID 7839 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 3-Fluorobenzylamine | HCID 66853 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (2-Bromo-ethyl)-(3-fluorobenzyl)-amine | HCID 21983578 | — |
反応手順
Combine 3-fluorobenzylamine (5.0 g, 0.0400 mol), fused sodium acetate (3.28 g, 0.0400 mol) and 1,2-dibromoethane (7.51 g, 0.0400 mol) and reflux for several hours. Pour the mixture into water and add sodium carbonate to create a basic pH. Remove the unreacted 1,2-dibromoethane by distillation. Extract the left-over residue with ether and evaporate to obtain the final, desired compound. The compound can form the hydrochloride salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091199B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-581af56aec3a433e9adb69447c08ffc7 |
| 出典メモ | uspto-grants-2006_08 |