Water → HCID 19697026、化合物
反応式
[CH2:1]([C:4]1[NH:5][C:6]2[C:11]([C:12]=1[CH2:13][C:14]#N)=[CH:10][C:9]([O:16][CH3:17])=[CH:8][CH:7]=2)[CH:2]=[CH2:3].[OH2:18].[OH-:19].[K+]>C(O)(=O)C>[CH2:1]([C:4]1[NH:5][C:6]2[C:11]([C:12]=1[CH2:13][C:14]([OH:19])=[O:18])=[CH:10][C:9]([O:16][CH3:17])=[CH:8][CH:7]=2)[CH:2]=[CH2:3]参加物
5
実験手順
0.08 mole of 2-allyl-5-methoxy-3-indolyl acetonitrile is added to a mixture of 140 ml. of alcohol, 100 ml. of water and 4.3 g. of KOH. The mixture is refluxed 15 hours and then brought to room temperature. Glacial acetic acid (60 ml.) is added, and the solution is filtered through a talc filter. The filtrate is diluted with 500 ml. of water, and the precipitated 2-allyl-5-methoxy-3-indolyl acetic acid is separated by filtration and dried.
後処理
- temperatureThe mixture is refluxed 15 hours
- custombrought to room temperature
- filtrationthe solution is filtered through a talc
- filtrationfilter
- additionThe filtrate is diluted with 500 ml
- customof water, and the precipitated 2-allyl-5-methoxy-3-indolyl acetic acid is separated by filtration
- customdried
出典と根拠
- ORDレコード
- ord-1639a2790b3f463380935713ab0230ab
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05721347
反応ノート
読み込み中…