Hydrochloric Acid → Ceftiofur Hydrochloride

HRID 863649

反応式

HRID 863649 の反応式
[ClH:1].[CH3:2][O:3]/[N:4]=[C:5](\[C:12]([NH:14][C@@H:15]1[C:18](=[O:19])[N:17]2[C:20]([C:33]([OH:35])=[O:34])=[C:21]([CH2:24][S:25][C:26]([C:28]3[O:32][CH:31]=[CH:30][CH:29]=3)=[O:27])[CH2:22][S:23][C@H:16]12)=[O:13])/[C:6]1[N:10]=[C:9]([NH2:11])[S:8][CH:7]=1>O.CC(C)=O>[CH3:2][O:3]/[N:4]=[C:5](\[C:12]([NH:14][C@@H:15]1[C:18](=[O:19])[N:17]2[C:20]([C:33]([OH:35])=[O:34])=[C:21]([CH2:24][S:25][C:26]([C:28]3[O:32][CH:31]=[CH:30][CH:29]=3)=[O:27])[CH2:22][S:23][C@H:16]12)=[O:13])/[C:6]1[N:10]=[C:9]([NH2:11])[S:8][CH:7]=1.[ClH:1]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 6328657Ceftiofur

生成物 1

HCID 9937686Ceftiofur Hydrochloride

試薬・触媒・溶媒 1

HCID 18366337Propan-2-one--water (1/1)溶媒

実験手順

The preparation of crystalline ceftiofur hydrochloride is considered to involve a typical crystallization. Several methods for the preparation of ceftiofur hydrochloride are described in U.S. Pat. No. 4,902,683. In one readily used method, once the hydrochloride salt is obtained by adding hydrochloric acid to a water/acetone solution of ceftiofur, the resulting solution is cooled slowly to obtain crystalline ceftiofur hydrochloride.

後処理

  1. temperaturethe resulting solution is cooled slowly

出典と根拠

ORDレコード
ord-c8c261744d074e3ca4caa76f3e176479
出典データセット
uspto-grants-1998_02
特許番号
US05721359

関連ノート

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