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1,2,3,4-Tetrahydro-6,7,8-trimethoxyisoquinoline → 2-[7-(3,4-Dimethoxyphenyl)-7-[(4-methylphenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7,8-trimethoxyisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2,3,4-Tetrahydro-6,7,8-trimethoxyisoquinoline | HCID 192723 | — |
| 反応物 | 4-[6-Bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene | HCID 19042093 | — |
| 反応物 | 5,6-Dimethoxyisoindoline | HCID 20074351 | — |
| 生成物 | 2-[7-(3,4-Dimethoxyphenyl)-7-[(4-methylphenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7,8-trimethoxyisoquinoline | HCID 10650882 | 65.7% |
反応手順
The procedure of Example 49 is repeated using 5.31 g 4-[6-bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene, 3.29 g of 5,6-dimethoxyisoindoline and 2.65 g of 6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline. This affords 4.52 g of the desired product as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05561141 |
| 出典データセット | uspto-grants-1996_10 |
| ORD ID | ord-40f69a31b6634ba6966d8fa3f5f32a00 |
| 出典メモ | uspto-grants-1996_10 |