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2,3-dihydro-6-methoxy-1H-isoindol-5-ol → alpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3-dihydro-6-methoxy-1H-isoindol-5-ol | HCID 10241135 | — |
| 反応物 | alpha-(5-Bromopentyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)thio]benzeneacetonitrile | HCID 10527448 | — |
| 生成物 | alpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile | HCID 10530307 | 74.2% |
反応手順
The procedure of Example 49 is used with 0.209 g of 2,3-dihydro-6-methoxy-1H-isoindol-5-ol (Example 105) and 0.57 g of α-(5-bromopentyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile. This affords 0.5 g of the desired product as a gray foam. MS(Hi res): m/z Calcd for C31H36N2SO4 533.2474 Found 533.2460
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05561141 |
| 出典データセット | uspto-grants-1996_10 |
| ORD ID | ord-83166a7d0e524228b00628184e0c8227 |
| 出典メモ | uspto-grants-1996_10 |