2-Methylthiomethyl-3,4,6-trifluoroaniline → 3,4,6-Trifluoro-2-methylaniline
反応式
CS[CH2:3][C:4]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:5]=1[NH2:6]>[Ni].C(O)C>[CH3:3][C:4]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:5]=1[NH2:6]参加物
4
実験手順
To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).
後処理
- filtrationAfter the catalyst is filtered off
- additionthe filtrate is added with water
- extractionextracted with dichloromethane
- dry with materialThe is dried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-909b848f416c4d2fb54608b479e09d05
- 出典データセット
- uspto-grants-1996_10
- 特許番号
- US05563138
反応ノート
読み込み中…