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p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate | HCID 17879412 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate | HCID 14517129 | 82.6% |
反応手順
To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05563138 |
| 出典データセット | uspto-grants-1996_10 |
| ORD ID | ord-a94c861ac06a4738b55bd7549e2d89d8 |
| 出典メモ | uspto-grants-1996_10 |