Acetic Acid → 5-Methoxy-4,6,7-trimethylindole-2-carboxylic acid

HRID 864388ノート

反応式

HRID 864388 の反応式
[CH3:1][O:2][C:3]1(C)[CH:11]=[C:10]([CH3:12])[C:9]2[C:5]([CH:6]=[C:7]([C:13]([O:15]CC)=[O:14])[N:8]=2)=[C:4]1[CH3:18].[OH-].[K+].[C:22](O)(=O)C>C(O)C>[CH3:1][O:2][C:3]1[C:4]([CH3:18])=[C:5]2[C:9](=[C:10]([CH3:12])[C:11]=1[CH3:22])[NH:8][C:7]([C:13]([OH:15])=[O:14])=[CH:6]2

参加物

5

反応物 3

HCID 176Acetic AcidHCID 14797Potassium HydroxideHCID 19418845Ethyl 5-methoxy-4,5,7-trimethylindole-2-carboxylate

生成物 1

HCID 194187895-Methoxy-4,6,7-trimethylindole-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of ethyl 5-methoxy-4,5,7 trimethylindole-2-carboxylate (PREPARATION 19, 1.04 g) in ethanol (30 ml) containing potassium hydroxide (45%, 2.5 ml) is heated under reflux for 1.5 hr. The mixture is acidified with acetic acid (2 ml) and concentrated under reduced pressure. The residue is mixed with water (200 ml) and filtered. The filter cake is washed with water and dried to give the title compound.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 1.5 hr
  3. concentrationconcentrated under reduced pressure
  4. additionThe residue is mixed with water (200 ml)
  5. filtrationfiltered
  6. washThe filter cake is washed with water
  7. customdried

出典と根拠

ORDレコード
ord-21f20374ba0d45d1805b48c1b1caccea
出典データセット
uspto-grants-1996_10
特許番号
US05563142

反応ノート

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