Triethylamine → HCID 19418948、化合物

HRID 864476ノート

反応式

HRID 864476 の反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH2:8][N:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]1=[O:18].C(N(CC)CC)C>ClCCl>[S:2]([O:6][CH2:7][CH2:8][N:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]1=[O:18])([CH3:1])(=[O:4])=[O:3]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 2721073-(2-Hydroxyethyl)-1,3-benzothiazol-2(3H)-one

生成物 1

HCID 19418948HCID 19418948、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Methanesulfonyl chloride (1.625 ml, 2.4 g, 21 mmol) in dichloromethane (10 ml) was added dropwise with stirring to 3-(2-hydroxyethyl)benzothiazolin-2-one (3.9 g, 20 mmol) (J. J. D'Amico and F. G. Bollinger; J. Heterocyclic Chemistry 1988, 25, 1601).and triethylamine (3.478 ml, 2.525 g, 25 mmol) in dichloromethane (80 ml) and stirred for one hour at room temperature. The reaction mixture was then washed with water and dried (MgSO4), filtered and the solvent evaporated in-vacuo to give the title product.

後処理

  1. washThe reaction mixture was then washed with water
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customthe solvent evaporated in-vacuo

出典と根拠

ORDレコード
ord-29298d48e9284d049fee26defbd9df5e
出典データセット
uspto-grants-1996_10
特許番号
US05563147

反応ノート

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