1,3-Dimethyl-2-imidazolidinone → 4-Methoxy-2-methylquinolin-8-OL
反応式
Cl[C:2]1[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:13])[CH:3]=1.CN1CCN(C)[C:16]1=[O:21].C[O-].[Na+]>CO>[OH:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[C:4]([CH3:13])[CH:3]=[C:2]2[O:21][CH3:16]参加物
5
反応条件
- 温度
- 150 °C
実験手順
A mixture of 4-chloro-8-hydroxy-2-methylquinoline (9 g), 1,3-dimethyl-2-imidazolidinone (100 ml) and 28% solution of sodium methoxide in methanol (135 ml) was stirred at 150° C. for 4 hours. The reaction mixture was cooled to ambient temperature followed by partition into ethyl acetate and water. The organic layer was washed with water and brine, dried over magnesium sulfate and concentrated in vacuo. The crystalline residue was washed with n-hexane to give 8-hydroxy-4-methoxy-2-methylquinoline (5.57 g).
後処理
- temperatureThe reaction mixture was cooled to ambient temperature
- customby partition into ethyl acetate and water
- washThe organic layer was washed with water and brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in vacuo
- washThe crystalline residue was washed with n-hexane
出典と根拠
- ORDレコード
- ord-6cc47415f3164f418fca43b418f003ae
- 出典データセット
- uspto-grants-1996_10
- 特許番号
- US05563162
反応ノート
読み込み中…