Acetyl chloride → Methyl 5-acetylbenzofuran-2-carboxylate

To a solution of 2-benzofuranoic acid methyl ester in carbon disulphide (240 ml) cooled to 5° C. was added acetyl chloride (70 ml) followed portionwise over 1 hour by aluminium trichloride (40 g). The mixture was heated under reflux for 42 hours before cooling and decanting the carbon disulphide. The residual complex was destroyed by the addition of iced water (50 ml) and 2N HCl (50 ml). The resulting mixture was extracted with ethyl acetate (3×200 ml). The organic layers were combined, washed with water (100 ml), dried (MgSO4) and concentrated. The residue was purified by flash column chromatography, eluting with ethyl acetate / hexane (10:90 to 40:60, v/v), to give methyl 5-acetylbenzofuran-2-carboxylate as a solid (3.099 g); NMR 2.68 (3H,s), 4.00(3H,s), 7.6-8.35(4H,m).

1. temperatureThe mixture was heated
2. temperatureunder reflux for 42 hours
3. temperaturebefore cooling
4. customdecanting the carbon disulphide
5. customThe residual complex was destroyed by the addition of iced water (50 ml) and 2N HCl (50 ml)
6. extractionThe resulting mixture was extracted with ethyl acetate (3×200 ml)
7. washwashed with water (100 ml)
8. dry with materialdried (MgSO4)
9. concentrationconcentrated
10. customThe residue was purified by flash column chromatography
11. washeluting with ethyl acetate / hexane (10:90 to 40:60

ORDレコード

ord-6987bc4d3aff4655b3cd6f2228d59476

出典データセット

uspto-grants-1996_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05563141