化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → [3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-thiophen-2-ylmethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (2-Thienylmethyl)amine | HCID 34005 | — |
| 反応物 | 3-[3-(3-Chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole | HCID 21983556 | — |
| 反応物 | 3-[3-(3-Bromo-propoxy)phenyl]-thieno[2,3-d]isoxazole | HCID 21983559 | — |
| 生成物 | [3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-thiophen-2-ylmethylamine | HCID 9799536 | 94% |
反応手順
The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 2-thiophenemethylamine and potassium carbonate essentially as described above in example 4. Combine the appropriate fractions and concentrate to give the title compound (0.35 g, 94% Yield) as an oil. Purity by LC/MS (APCI)=100% area, [M+H]+=371 m/e.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091199B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-6bb6ce2fe8a0479ca1d5204a25a71496 |
| 出典メモ | uspto-grants-2006_08 |