Hydrochloric Acid → 4-Amino-1-(4-pyridyl)piperidine trihydrochloride hydrate

HRID 864839

反応式

HRID 864839 の反応式
C([NH:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)(=[O:3])C.[ClH:17]>>[OH2:3].[ClH:17].[ClH:17].[ClH:17].[NH2:4][CH:5]1[CH2:6][CH2:7][N:8]([C:11]2[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=2)[CH2:9][CH2:10]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 189184354-Acetylamino-1-(4-pyridyl)piperidine

生成物 1

HCID 189186074-Amino-1-(4-pyridyl)piperidine trihydrochloride hydrate

実験手順

The product from step (iii) (0.52 g) in 1 molar hydrochloric acid (11.9 ml) was heated at 95° C. for 5 hours. The solvent was evaporated and the residue, on drying over potassium hydroxide in vacuo gave 4-amino-1-(4-pyridyl)piperidine trihydrochloride hydrate, 0.70 g as a light brown solid: m.p >300° C. ; NMR (d6DMSO) δ8.28(4H,m), 7.22(2H,d), 4.27(2H,bd), 3.5 to 3.15(3H+H2O), 2.09(2H,m), 1.59(2H,dq); m/e 178(M+H)+ ; calculated for C10H15N3. 3HCl. 1.0.75 H2O: C, 40.0; H, 6.5; N, 14.0. found: C, 40.4; H, 6.3; N, 13.5%.

後処理

  1. customThe solvent was evaporated
  2. dry with materialthe residue, on drying over potassium hydroxide in vacuo

出典と根拠

ORDレコード
ord-14e66881262c4d30b3cff80620140d10
出典データセット
uspto-grants-1996_10
特許番号
US05563141

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