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Potassium Carbonate → [3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-thiophen-3-yl-methylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Thiophenemethylamine | HCID 2776381 | — |
| 反応物 | 3-[3-(3-Chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole | HCID 21983556 | — |
| 反応物 | 3-[3-(3-Bromo-propoxy)phenyl]-thieno[2,3-d]isoxazole | HCID 21983559 | — |
| 生成物 | [3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-thiophen-3-yl-methylamine | HCID 69652986 | 86% |
反応手順
The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-thiophenemethylamine and potassium carbonate essentially as described above in example 4. Combine the appropriate fractions and concentrate to give the title compound (0.32 g, 86% Yield) as an oil. Purity by LC/MS (APCI)=98%, [M+H]+=371 m/e.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091199B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-92bcf849b3e149aea25a639e139f430f |
| 出典メモ | uspto-grants-2006_08 |