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Thionyl Chloride → 1-Benzyl-3-(chloromethyl)pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (1-Benzylpyrrolidin-3-yl)methanol | HCID 5176654 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 1-Benzyl-3-(chloromethyl)pyrrolidine | HCID 12364518 | — |
反応手順
To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethyl pyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723444 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-1537debbdfcd4c9fb2d97af472b6fc7c |
| 出典メモ | uspto-grants-1998_03 |