2,5-Dichlorophenol → 2,5-Dichlorophenyl Dimethyloctylsilyl Ether

HRID 865323

反応式

HRID 865323 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].N1C=CN=C1.Cl[Si:16]([CH3:26])([CH3:25])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>CN(C)C=O.[Cl-].[Na+]>[CH3:25][Si:16]([O:9][C:3]1[CH:4]=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=1[Cl:1])([CH3:26])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

参加物

6

反応物 3

HCID 662,5-DichlorophenolHCID 795ImidazoleHCID 87482Chlorodimethyloctylsilane

生成物 1

HCID 539888402,5-Dichlorophenyl Dimethyloctylsilyl Ether

試薬・触媒・溶媒 2

HCID 5234Sodium Chloride溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 3.75 g (0.023 mole) 2,5-dichlorophenol in 30 ml N,N-dimethylformamide are added 5.58 g (0.082 mole) imidazole and 16.6 ml (0.070 mole) chlorodimethyloctyl silane under argon. After stirring at room temperature for two hours, the mixture is diluted with an aqueous saturated sodium chloride solution and extracted with ether. The combined organic extracts are dried and condensed. The product is purified by column chromatography.

後処理

  1. extractionextracted with ether
  2. customThe combined organic extracts are dried
  3. customcondensed
  4. customThe product is purified by column chromatography

出典と根拠

ORDレコード
ord-c6e4eef05fd94331a9e1f324b60fab4a
出典データセット
uspto-grants-1996_10
特許番号
US05565543

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