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Tetrabutylammonium Fluoride → 2,6-Dipropyl-4-(2-hydroxyethyl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 反応物 | t-Butyldimethylsilyloxy-2,6-dipropyl-4-(2-hydroxyethyl)-benzene | HCID 19080442 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2,6-Dipropyl-4-(2-hydroxyethyl)phenol | HCID 19080373 | — |
反応手順
To a solution of 1.0 g (2.98 mrnol) of the product of Step C in 3.0 mL of THF was added 3.57 mL (3.57 mmol) of 1.0 N solution of tetrabutylammonium fluoride in THF. After 15 minutes TLC indicated that the reaction was complete. The reaction mixture was concentrated and then purified by flash chromatography (silica gel, hexane/ethyl acetate 3:1) to give 1.13 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05565485 |
| 出典データセット | uspto-grants-1996_10 |
| ORD ID | ord-358f89dd7cad4de78ad84ce485f328f1 |
| 出典メモ | uspto-grants-1996_10 |